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For example, obesity is a risk factor for AD and disruption of insulin signalling in the brain leads to a higher risk of AD 29 , however ALS patients tend to be hypermetabolic and it has been shown that increasing glucose levels in models of ALS is protective 30

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6.3 Incretin Receptor Activation Normalizes Insulin Sensitization Insulin sensitivity in the brain is reduced in several animal models of AD and PD, most likely driven by the chronic inflammation response and the release of proinflammatory cytokines that block growth factor signaling [23, 88, 124,125,126,127]

Andrew Huberman You do this in the morning before you train